SPL Set ID: 99476e8c-2527-4cb0-9d67-9f9cd91343c6
1 drug(s) with this SPL Set ID
IGALMI contains dexmedetomidine, an alpha-2 adrenergic receptor agonist, present as dexmedetomidine hydrochloride, the S-enantiomer of medetomidine chemically described as 4-[(1S)-1- (2, 3-dimethylphenyl) ethyl]-1H-imidazole hydrochloride. The empirical formula is C 13 H 16 N 2 ∙HCl with a molecular weight of 236.7 g/mol. The structural formula of dexmedetomidine hydrochloride is: Dexmedetomidine hydrochloride is a white or almost white powder that is freely soluble in water and has a pKa of 7.1. Its partition coefficient in octanol/water at pH 7.4 is 2.89. IGALMI is for sublingual or buccal use. Each IGALMI sublingual film contains 120 mcg or 180 mcg of dexmedetomidine equivalent to 141.8 mcg and 212.7 mcg of dexmedetomidine hydrochloride, respectively. IGALMI contains the following inactive ingredients: FD&C Blue #1 colorant, hydroxypropyl cellulose, peppermint oil, polyethylene oxide, and sucralose. Chemical Structure