SPL Set ID: 39a0a789-778f-4695-b3a9-61643e6396cd

Denosumab-bnht is a human IgG2 monoclonal antibody with affinity and specificity for human RANKL (receptor activator of nuclear factor kappa-B ligand). Denosumab-bnht has an approximate molecular weight of 147 kDa and is produced in genetically engineered mammalian (Chinese hamster ovary) cells. Conexxence (denosumab-bnht) injection is a sterile, preservative-free, clear, colorless to pale yellow solution for subcutaneous use. Each 1 mL single-dose prefilled syringe of Conexxence contains 60 mg denosumab-bnht (60 mg/mL solution), 0.23 mg glacial acetic acid, 0.1 mg polysorbate 20, 1.07 mg sodium acetate, 47 mg sorbitol, and Water for Injection (USP). The pH is 5.2.