SPL Set ID: 1e9a37e2-f28a-4373-bf0f-3e9b60f42d8a
1 drug(s) with this SPL Set ID
OMNISCAN (gadodiamide) Injection is the formulation of the gadolinium complex of diethylenetriamine pentaacetic acid bismethylamide, and is an injectable, nonionic extracellular enhancing agent for magnetic resonance imaging. OMNISCAN is administered by intravenous injection. OMNISCAN is provided as a sterile, clear, colorless to slightly yellow, aqueous solution. Each 1 mL contains 287 mg gadodiamide and 12 mg caldiamide sodium in Water for Injection. The pH is adjusted between 5.5 and 7.0 with hydrochloric acid and/or sodium hydroxide. OMNISCAN contains no antimicrobial preservative. OMNISCAN is a 0.5 mol/L solution of aqua[5,8-bis(carboxymethyl)-11-[2-(methylamino)-2-oxoethyl]-3-oxo-2,5,8,11-tetraazatridecan-13-oato (3-)-N 5 , N 8 , N 11 , O 3 , O 5 , O 8 , O 11 , O 13 ] gadolinium hydrate, with a molecular weight of 573.66 (anhydrous), an empirical formula of C 16 H 28 GdN 5 O 9 ∙xH 2 O, and the following structural formula: Pertinent physicochemical data for OMNISCAN are noted below: PARAMETER Osmolality (mOsmol/kg water) @ 37°C 789 Viscosity (cP) @ 20°C 2 @ 37°C 1.4 Density (g/mL) @ 25°C 1.14 Specific gravity @ 25°C 1.15 OMNISCAN has an osmolality approximately 2.8 times that of plasma at 37°C and is hypertonic under conditions of use. Chemical Structure