FLUOCINONIDE FLUOCINONIDE PADAGIS ISRAEL PHARMACEUTICALS LTD FDA Approved Fluocinonide Gel USP, 0.05% is intended for topical administration. The active component is the corticosteroid fluocinonide, which is the 21-acetate ester of fluocinolone acetonide and has the chemical name pregna-1,4-diene-3,20-dione,21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(6a,11b,16a)-. It has the following chemical structure: Mol. Formula: C 26 H 32 F 2 O 7 Mol. Wt: 494.53 Fluocinonide Gel USP, 0.05% contains fluocinonide 0.5 mg/g in a specially formulated gel base consisting of carbomer 980, edetate disodium, propyl gallate, propylene glycol, sodium hydroxide (to adjust pH) and purified water. This clear, colorless, thixotropic vehicle is greaseless, non-staining and completely water miscible. In the Fluocinonide Gel USP, 0.05% formulation, the active ingredient is totally in solution. fluocinonide chemical structure
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Substance Fluocinonide
Route
TOPICAL
Applications
ANDA209030

Drug Facts

Composition & Profile

Strengths
0.05 % 15 g 30 g 60 g
Quantities
24 count
Treats Conditions
Indications And Usage Fluocinonide Gel Usp 0 05 Is Indicated For The Relief Of The Inflammatory And Pruritic Manifestations Of Corticosteroid Responsive Dermatoses

Identifiers & Packaging

Container Type BOX
UNII
2W4A77YPAN
Packaging

HOW SUPPLIED Fluocinonide Gel USP, 0.05% is supplied in the following: 15 g (NDC 45802- 761 -15) 30 g (NDC 45802- 761 -30) and 60 g (NDC 45802- 761 -60) tubes. Store at 20°- 25°C (68°- 77°F) [see USP Controlled Room Temperature] Manufactured by Padagis®, Yeruham, Israel www.padagis.com Rev 08-24 7D000 RC PH2; PACKAGE/LABEL PRINCIPAL DISPLAY PANEL NDC 45802-761-30 Rx Only Fluocinonide Gel USP, 0.05% For External Use Only. Not For Ophthalmic Use. NET WT 30 g Fluocinonide Gel USP, 0.05% carton image

Package Descriptions
  • HOW SUPPLIED Fluocinonide Gel USP, 0.05% is supplied in the following: 15 g (NDC 45802- 761 -15) 30 g (NDC 45802- 761 -30) and 60 g (NDC 45802- 761 -60) tubes. Store at 20°- 25°C (68°- 77°F) [see USP Controlled Room Temperature] Manufactured by Padagis®, Yeruham, Israel www.padagis.com Rev 08-24 7D000 RC PH2
  • PACKAGE/LABEL PRINCIPAL DISPLAY PANEL NDC 45802-761-30 Rx Only Fluocinonide Gel USP, 0.05% For External Use Only. Not For Ophthalmic Use. NET WT 30 g Fluocinonide Gel USP, 0.05% carton image

Overview

Fluocinonide Gel USP, 0.05% is intended for topical administration. The active component is the corticosteroid fluocinonide, which is the 21-acetate ester of fluocinolone acetonide and has the chemical name pregna-1,4-diene-3,20-dione,21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(6a,11b,16a)-. It has the following chemical structure: Mol. Formula: C 26 H 32 F 2 O 7 Mol. Wt: 494.53 Fluocinonide Gel USP, 0.05% contains fluocinonide 0.5 mg/g in a specially formulated gel base consisting of carbomer 980, edetate disodium, propyl gallate, propylene glycol, sodium hydroxide (to adjust pH) and purified water. This clear, colorless, thixotropic vehicle is greaseless, non-staining and completely water miscible. In the Fluocinonide Gel USP, 0.05% formulation, the active ingredient is totally in solution. fluocinonide chemical structure

Indications & Usage

Fluocinonide Gel USP, 0.05% is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Dosage & Administration

Fluocinonide Gel USP, 0.05% is generally applied to the affected area as a thin film from two to four times daily depending on the severity of the condition. Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions. If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.

Warnings & Precautions
No warnings available yet.
Contraindications

Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparations.

Adverse Reactions

The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence: Burning Hypertrichosis Maceration of the Skin Itching Acneiform Eruptions Secondary Infection Irritation Hypopigmentation Skin Atrophy Dryness Perioral Dermatitis Striae Folliculitis Allergic Contact Dermatitis Miliaria To report SUSPECTED ADVERSE REACTIONS , contact Padagis ® at 1-866-634-9120 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.


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