SPL Set ID: f6d82772-638c-4584-b9d3-8833669f5963

Lactated Ringer’s Injection, USP is a sterile, nonpyrogenic solution for fluid and electrolyte replenishment in a single-dose container intended for intravenous administration. Composition, osmolarity, pH, ionic concentration and caloric content are shown in Table 1. Table 1 Size (mL) Composition (g/L) Osmolarity Normal physiologic osmolarity range is approximately 280 to 310 mOsmol/L. (mOsmol/L) (calc) pH pH may be adjusted with Hydrochloric Acid NF or Sodium Hydroxide NF. Ionic Concentration (mEq/L) Caloric Content (kcal/L) Sodium Chloride, USP Sodium Lactate Potassium Chloride, USP Calcium Chloride, USP Sodium Potassium Calcium Chloride Lactate Lactated Ringer’s Injection, USP 1000 6 3.1 0.3 0.2 274 6.2 (6.0 to 7.5) 130 4 3 109 28 9 The chemical name, structural formula, and molecular weight of the active ingredients are shown in Table 2. Table 2 The formulas of the active ingredients are: Ingredients Molecular Formula Molecular Weight Sodium Chloride USP Na + CI − 58.44 Sodium Lactate 112.06 Potassium Chloride USP K + CI − 74.55 Calcium Chloride Dihydrate USP 147.02 Not made with natural rubber latex, PVC or DEHP. The plastic container is made from a homogenous blend of polypropylene and thermoplastic modifier developed for parenteral drugs. The container is a closed system and is not dependent upon entry of external air during administration. The closure system has two ports; one for the administration set and the other is a medication addition site. Each port has a tamper evident cover [see Dosage and Administration (2.3) ] . Sodium Lactate Molecular Formula Illustration Calcium Chloride Dihydrate USP Molecular Formula