SPL Set ID: f278f0d8-4062-420a-97c3-3a8b88253a08

Octreotide Acetate Injection, a cyclic octapeptide prepared as a clear sterile solution of octreotide, acetate salt, in a buffered acetate solution for administration by deep subcutaneous or IV injection. Octreotide acetate, known chemically as L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2 → 7)-disulfide; [R-(R*, R*)] acetate salt, is a long-acting octapeptide with pharmacologic actions mimicking those of the natural hormone somatostatin. Octreotide Acetate Injection is available as: sterile 1 mL single dose vials in 2 strengths, containing 100 mcg and 500 mcg octreotide (as acetate), and sterile 5 mL multiple dose vials in 2 strengths, containing 200 mcg/mL and 1,000 mcg/mL of octreotide (as acetate). Each mL of the single dose vial also contains: sodium chloride…………………..……... 7 mg glacial acetic acid, USP ………………… 2 mg sodium acetate trihydrate, USP ………… 2 mg water for injection, USP ……………qs to 1 mL Each mL of the multiple dose vials also contains: sodium chloride ………………………… 7 mg glacial acetic acid, USP ………………… 2 mg sodium acetate trihydrate, USP ……….. . 2 mg phenol, USP ……………………………. 5 mg water for injection, USP .………….. qs to 1 mL The molecular weight of octreotide acetate is 1019.3 g/mol (free peptide, C 49 H 66 N 10 O 10 S 2 ) and its amino acid sequence is: structural formula