SPL Set ID: e6467385-6990-498c-8a0e-f4a40ef33cb7
1 drug(s) with this SPL Set ID
Naloxone Hydrochloride Injection, USP is a sterile, nonpyrogenic solution of naloxone hydrochloride in water for injection. Each milliliter (mL) in the 1 mL single dose syringe contains 0.4 mg (400 micrograms) of naloxone hydrochloride, 8.9 mg of sodium chloride to adjust tonicity, in Water for Injection. Each milliliter (mL) in the 2 mL single dose syringe contains 1 mg of naloxone hydrochloride, 8.35 mg of sodium chloride to adjust tonicity, in Water for Injection. The pH is 3.0-4.0 with hydrochloric acid used, if needed, for pH adjustment. Sealed under nitrogen. Naloxone Hydrochloride Injection, USP may be administered intravenously, intramuscularly, or subcutaneously. Naloxone, an opioid antagonist, is a synthetic congener of oxymorphone. It differs from oxymorphone in that the methyl group on the nitrogen atom is replaced by an allyl group. Naloxone Hydrochloride, USP is a chemically designated 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride (C 19 H 21 NO 4 • HCl), a white to slightly off-white powder soluble in water, in dilute acids, and in strong alkali; slightly soluble in alcohol; practically insoluble in ether and chloroform. It has a molecular weight of 363.84. It has the following structural formula: naloxone syringe structure