SPL Set ID: d4af73d1-c97e-4418-9e24-007b10af0bd9

Prazosin hydrochloride, USP a quinazoline derivative, is the first of a new chemical class of antihypertensives. It is the hydrochloride salt of 1-(4-amino-6,7-dimethoxy- 2-quinazolinyl)-4-(2-furoyl) piperazine and its structural formula is: Molecular formula C 19 H 21 N 5 O 4• HCl It is a white to tan powder, slightly soluble in methanol, in dimethyl formamide, in dimethyl acetamide, very slightly soluble in alcohol, practically insoluble in chloroform and in acetone. It has a molecular weight of 419.87. Each capsule for oral administration contains prazosin hydrochloride, USP equivalent to 1 mg, 2 mg or 5 mg of prazosin. Inert ingredients in the formulations are: sucrose, corn starch, sodium lauryl sulfate, microcrystalline cellulose, colloidal silicon dioxide and magnesium stearate. The empty hard gelatin capsule shell contains gelatin and titanium dioxide. In addition, the 2 mg and 5 mg empty hard gelatin capsule shell also contain FD&C Blue 1 and FD&C Red 3. The empty hard gelatin capsule shells are imprinted with edible black ink containing shellac, potassium hydroxide and black iron oxide. Prazosin hydrochloride capsules, USP meets USP Dissolution Test 3 . structure