SPL Set ID: d21ce241-b05a-413e-b19a-249ae42012a8

Entacapone is available as tablets containing 200 mg entacapone, USP. Entacapone is an inhibitor of catechol-O-methyltransferase (COMT), used in the treatment of Parkinson’s disease as an adjunct to levodopa and carbidopa therapy. It is a nitrocatechol-structured compound with a relative molecular mass of 305.29. The chemical name of entacapone is (E)-2-cyano­3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide. Its empirical formula is C 14 H 15 N 3 O 5 and its structural formula is: The inactive ingredients of the entacapone tablets, USP are microcrystalline cellulose, mannitol, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate, hydrogenated vegetable oil, hypromellose, glycerin, titanium dioxide, iron oxide yellow, sucrose, polysorbate 80 and iron oxide red. FDA approved dissolution testing specifications differ from USP. structure