SPL Set ID: cd0e7af2-7704-49ce-bde9-f645294b6788

Adalimumab-aqvh is a tumor necrosis factor blocker. Adalimumab-aqvh is a recombinant human IgG1 monoclonal antibody with human derived heavy and light chain variable regions and human IgG1:k constant regions. Adalimumab-aqvh is produced by recombinant DNA technology in a mammalian cell (Chinese Hamster Ovary (CHO)) expression system and is purified by a process that includes specific viral inactivation and removal steps. It consists of 1330 amino acids and has a molecular weight of approximately 148 kilodaltons. YUSIMRY (adalimumab-aqvh) injection is supplied as a sterile, preservative-free solution for subcutaneous administration. The drug product is supplied as either a single-dose, prefilled pen (YUSIMRY PEN) or as a single-dose, 1 mL prefilled glass syringe. The solution of YUSIMRY is a clear to slightly opalescent, colorless to slightly yellow solution, with a pH of about 5.3. Each 40 mg/0.8 mL prefilled syringe or pen delivers 0.8 mL (40 mg) of drug product. Each 0.8 mL of YUSIMRY contains adalimumab-aqvh (40 mg), glycine (9.61 mg), L-histidine (0.51 mg), L-histidine hydrochloride monohydrate (4.34 mg), polysorbate 80 (0.80 mg), sodium chloride (2.06 mg) and Water for Injection, USP. Sodium hydroxide is added as necessary to adjust the pH.