SPL Set ID: cb966bcb-3af7-4dbe-b540-58d473b891e5
1 drug(s) with this SPL Set ID
Topiramate, USP is a sulfamate-substituted monosaccharide. Topiramate capsules are available as 15 mg and 25 mg capsules for oral administration as whole capsules or opened and sprinkled onto soft food. Topiramate, USP is a white to off white powder. Topiramate is most soluble in alkaline solutions containing sodium hydroxide or sodium phosphate and having a pH of 9 to 10. It is freely soluble in dichloromethane. The solubility in water is 9.8 mg/mL. Its saturated solution has a pH of 6.3. Topiramate has the molecular formula C 12 H 21 NO 8 S and a molecular weight of 339.36. Topiramate is designated chemically as 2,3:4,5- Di- O -isopropylidene-β-D-fructopyranose sulfamate (USP) and has the following structural formula: Topiramate capsules, USP contain topiramate-coated spheres in a hard gelatin capsule. The inactive ingredients are black iron oxide, cellulose acetate, gelatin, hypromellose, potassium hydroxide, povidone, propylene glycol, shellac, sodium lauryl sulfate, sugar sphere, talc and titanium dioxide. topi-spnk-1