SPL Set ID: c85b2c62-3c33-4cbc-8b79-d5e17851a1b4

Docetaxel is an antineoplastic agent belonging to the taxoid family. It is prepared by semisynthesis beginning with a precursor extracted from the renewable needle biomass of yew plants. The chemical name for docetaxel (anhydrous) is (2R,3S)-N-carboxy-3-phenylisoserine,N- tert -butyl ester, 13-ester with 5β-20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate. Docetaxel (anhydrous) has the following structural formula: Docetaxel anhydrous, USP is a white to almost-white powder with molecular formula of C 43 H 53 NO 14 , and a molecular weight of 807.88. It is highly lipophilic and practically insoluble in water. One-vial DOCETAXEL INJECTION DOCETAXEL INJECTION USP is a sterile, non-pyrogenic, yellowish colour solution at 20 mg/mL concentration. Each mL contains 20 mg docetaxel (anhydrous) and 4 mg citric acid anhydrous in 0.54 grams polysorbate 80 and 0.395 grams dehydrated alcohol (50% v/v) solution. DOCETAXEL INJECTION USP is available in single-dose vials containing 20 mg (1 mL), 80 mg (4 mL), or 160 mg (8 mL) docetaxel (anhydrous). DOCETAXEL INJECTION USP requires NO prior dilution with a diluent and is ready to add to the infusion solution. spl-docetaxel-chemical-structure