SPL Set ID: c4d92cce-e899-4f14-b19c-5e17f9922215
1 drug(s) with this SPL Set ID
Sapropterin dihydrochloride is an orally administered Phenylalanine Hydroxylase activator (or PAH activator). Sapropterin dihydrochloride, the active pharmaceutical ingredient in sapropterin dihydrochloride tablets, is a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4). Sapropterin dihydrochloride is an off-white to light yellow powder. The chemical name of sapropterin dihydrochloride is (6R)-2-amino-6[(3R,2S)-dihydroxypropyl]-4-oxo-5,6,7,8- tetrahydropteridine dihydrochloride and the molecular formula is C 9 H 15 N 5 O 3 ·2HCl with a molecular weight of 314.17. Sapropterin dihydrochloride has the following structural formula: Sapropterin dihydrochloride is supplied as tablets containing 100 mg of sapropterin dihydrochloride (equivalent to 77 mg of sapropterin base). Tablets are off white to light yellow, mottled, round shaped tablets debossed with “ZS” on one side and plain on other side. Each tablet contains the following inactive ingredients: Ascorbic acid, crospovidone, anhydrous dibasic calcium phosphate, mannitol, riboflavin, and sodium stearyl fumarate. Sapropterin dihydrochloride-chem-structure.jpg