SPL Set ID: c37c251f-92e9-40f0-8b0c-00d42875d776

Tobramycin sulfate, a water-soluble antibiotic of the aminoglycoside group, is derived from the actinomycete Streptomyces tenebrarius . Tobramycin for injection, USP is supplied as a sterile white to off-white lyophilized powder or cake and is intended for reconstitution with 30 mL of Sterile Water for Injection, USP. Sulfuric acid and/or sodium hydroxide may have been added during manufacture to adjust the pH between 6.0 and 8.0. Each vial contains tobramycin sulfate equivalent to 1,200 mg of tobramycin, USP. After reconstitution, the solution will contain 40 mg of tobramycin, USP per mL. The product contains no preservative or sodium bisulfite. Tobramycin sulfate is, O -3-amino-3-deoxy-α-D-glucopyranosyl-(1→4)- O -[2,6-diamino-2,3,6-trideoxy-α-D -ribo- hexopyranosyl-(1→6)]-2-deoxy-L-streptamine, sulfate (2:5) (salt) and has the molecular formula (C 18 H 37 N 5 O 9 )2•5H 2 SO 4 . The molecular weight is 1,425.45. The structural formula for tobramycin, USP is as follows: A pharmacy bulk package is a container of a sterile preparation for parenteral use that contains many single doses. The contents are intended for use in a pharmacy admixture service and are restricted to the preparation of admixtures for intravenous infusion (see DOSAGE AND ADMINISTRATION , Directions for proper use of Pharmacy Bulk Package ). tobramycin-str