SPL Set ID: c2daaefa-6c24-4e91-9176-61e9713069fa
1 drug(s) with this SPL Set ID
Naloxone hydrochloride, an opioid antagonist, is a synthetic congener of oxymorphone. In structure it differs from oxymorphone in that the methyl group on the nitrogen atom is replaced by an allyl group. It is known chemically as 17-allyl-4,5α-epoxy,3-14-dihydroxymorphinan-6-one hydrochloride, dihydrate. It has a molecular weight of 399.87, and the following structural formula: Naloxone hydrochloride dihydrate occurs as a white to slightly off-white powder, and is soluble in water, in dilute acids, and in strong alkali; slightly soluble in alcohol; practically insoluble in ether and in chloroform. Naloxone hydrochloride injection is available as a sterile solution for intravenous, intramuscular, and subcutaneous administration. Each mL contains 0.4 mg of naloxone hydrochloride. Each mL contains 9 mg of sodium chloride. The pH is adjusted to 3.5 ± 0.5 with hydrochloric acid. The air in the syringes has been displaced by nitrogen gas. Structure