SPL Set ID: c17bff97-8347-43f8-822e-1cb9736562b6

The active ingredient in sevelamer carbonate for oral suspension is sevelamer carbonate, a polymeric amine that binds phosphate and is meant for oral administration. It was developed as a pharmaceutical alternative to sevelamer hydrochloride. Sevelamer carbonate is an anion exchange resin, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion. While the counterions differ for the two salts, the polymer itself, the active moiety involved in phosphate binding, is the same. Sevelamer Carbonate is known chemically as poly(allylamine-co-N,N'-diallyl-1,3-diamino-2-hydroxypropane) carbonate salt. Sevelamer Carbonate is white to off-white powder, practically insoluble in water. The structure is represented in Figure 1. Figure 1: Chemical Structure of Sevelamer Carbonate a, b = number of primary amine groups a + b = 9 c = number of cross-linking groups c = 1 m = large number to indicate extended polymer network Sevelamer carbonate for oral suspension: Each packet of Sevelamer carbonate for oral suspension contains 0.8 g or 2.4 g of sevelamer carbonate on an anhydrous basis. The inactive ingredients are mannitol, neotame, sodium chloride, Tutti frutti flavor, and yellow oxide of iron. description