SPL Set ID: bf6a7f59-5a10-49fe-9e57-19e3ba202918
1 drug(s) with this SPL Set ID
Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution 0.2%/0.5%, sterile, is a relatively selective alpha-2 adrenergic receptor agonist with a non-selective beta-adrenergic receptor inhibitor (topical intraocular pressure lowering agent). The structural formulae are: Brimonidine tartrate: 5-bromo-6-(2-imidazolidinylideneamino) quinoxaline L-tartrate; MW= 442.22 Timolol maleate: (-)-1-( tert -butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)-oxy]-2-propanol maleate (1:1) (salt); MW= 432.49 as the maleate salt In solution, Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution 0.2%/0.5% has a clear, greenish-yellow color. It has an osmolality of 260-330 mOsmol/kg and a pH during its shelf life of 6.5-7.3. Brimonidine tartrate appears as a white, or slightly yellowish, or slightly brownish powder and is soluble in water and practically insoluble in anhydrous ethanol and toluene. Timolol maleate appears as a white to practically white powder and is soluble in water, methanol, and alcohol, sparingly soluble in chloroform and propylene glycol and insoluble in ether and cyclohexane. Each mL of Brimonidine Tartrate/Timolol Maleate Ophthalmic Solutioncontains the active ingredients brimonidine tartrate 0.2% and timolol 0.5% with the inactive ingredients benzalkonium chloride 0.005%; sodium phosphate, monobasic; sodium phosphate, dibasic; water for injection; and hydrochloric acid and/or sodium hydroxide to adjust pH. structure structure1