SPL Set ID: bf02ffd0-cc5d-446b-b648-378f6885052f
1 drug(s) with this SPL Set ID
Fentanyl transdermal system contains fentanyl, an opioid agonist, for transdermal administration. The amount of fentanyl released from each system per hour is proportional to the surface area (25 mcg/hour per 10.5 cm 2 ). The composition per unit area of all transdermal system sizes is identical. Strength Nominal delivery rate per hour (mcg/hour) Size (cm 2 ) Fentanyl Content (mg) 12 Nominal delivery rate is 12.5 mcg/hour 5.35 1.38 25†† 10.7 2.76 37.5†† 16.05 4.14 50†† 21.4 5.52 62.5†† 26.75 6.90 75†† 32.1 8.28 87.5†† 37.45 9.66 100†† 42.8 11.04 The molecular weight of fentanyl base is 336.5 g/mol, and the empirical formula is C 22 H 28 N 2 O. The n-octanol: water partition coefficient is 860:1. The pKa is 8.4. The chemical name is N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl) propanamide. The structural formula is: Fentanyl transdermal system is a rectangular transparent unit comprising a release liner and two functional layers. Proceeding from the outer surface toward the surface adhering to skin, these functional layers are: 1) a backing layer of polyethylene terephalate film; 2) a drug-in-adhesive layer. Before use, a release liner covering the drug-in-adhesive layer is removed and discarded. Structure Patch