SPL Set ID: b7919013-1511-44f0-a759-3fa78a9fa178
1 drug(s) with this SPL Set ID
Sorafenib, a kinase inhibitor, is the tosylate salt of sorafenib. Sorafenib tosylate, USP has the chemical name 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]- N -methylpyridine-2-carboxamide, tosylate. The molecular formula of sorafenib tosylate, USP is C 21 H 16 ClF 3 N 4 O 3• C 7 H 8 O 3 S and the molecular weight of sorafenib tosylate, USP is 637.03 g/mole. Its structural formula is: Sorafenib tosylate, USP is a cream to yellow crystalline powder. Sorafenib tosylate, USP is practically insoluble in aqueous media, slightly soluble in ethanol and soluble in PEG 400. Sorafenib tablets, USP for oral use are supplied as film-coated tablets containing 200 mg sorafenib equivalent to 274 mg sorafenib tosylate, USP and the following inactive ingredients: carboxymethylcellulose calcium, croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, red iron oxide, sodium lauryl sulfate and titanium dioxide. Sorafenib Tosylate Structural Formula