SPL Set ID: b080eb92-fc72-4ce6-a7ab-3f9ce2415526
1 drug(s) with this SPL Set ID
Methotrexate is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis. Chemically methotrexate is L-(+)- N -[ p -[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]-benzoyl]glutamic acid. The structural formula is: C 20 H 22 N 8 O 5 M.W.=454.44 Methotrexate for injection (Preservative Free) is sterile and non-pyrogenic and may be given by the intramuscular, intravenous, intra-arterial or intrathecal route. (See DOSAGE AND ADMINISTRATION .) Methotrexate for Injection, USP, Lyophilized, Preservative Free , for single use only , is available in 1 gram vials. Each 1 gram vial of lyophilized powder contains methotrexate sodium equivalent to 1 gram methotrexate. Contains no preservative. Sodium hydroxide and, if necessary, hydrochloric acid are added during manufacture to adjust the pH. The 1 gram vial contains approximately 7 mEq sodium. structural formula