SPL Set ID: ac824c7e-9c9f-487b-ad2f-d50eaef5cbda

Lamivudine (also known as 3TC), a synthetic nucleoside analogue with activity against HIV-1 and HBV. The chemical name of lamivudine is (2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one. Lamivudine is the (-) enantiomer of a dideoxy analogue of cytidine. Lamivudine has also been referred to as (-)2′,3′-dideoxy, 3′-thiacytidine. It has a molecular formula of C 8 H 11 N 3 O 3 S and a molecular weight of 229.3 g per mol. It has the following structural formula: Lamivudine is a white to off-white crystalline solid with a solubility of approximately 70 mg per mL in water at 20°C. Lamivudine Tablets, USP are for oral administration. Each scored 150-mg film-coated tablet contains 150 mg of lamivudine and the inactive ingredients microcrystalline cellulose, sodium starch glycolate, colloidal silicon dioxide, povidone, magnesium stearate, and opadry white which is composed of Hydroxy Propyl methylcellulose 2910/ Hypromellose 5cP, Titanium dioxide, Polyethylene glycol 400 (Macrogol). Each 300-mg film-coated tablet contains 300 mg of lamivudine and the inactive ingredients microcrystalline cellulose, sodium starch glycolate, colloidal silicon dioxide, povidone, magnesium stearate, and opadry white which is composed of Hydroxy Propyl methylcellulose 2910/ Hypromellose 5cP, Titanium dioxide, Polyethylene glycol 400 (Macrogol). Chemical Structure