SPL Set ID: a7ae9c31-e14f-4cf9-9ab3-850519f1a87c

Deferasirox is an iron-chelating agent provided as a tablet for oral use. Deferasirox is designated chemically as 4-[3,5-bis(2-hydroxyphenyl)-1 H -1,2,4-triazol-1-yl]benzoic acid and has the following structural formula: Deferasirox is a white to slightly yellow powder. It is sparingly soluble in N, N-dimethyl formamide and dimethyl sulfoxide, slightly soluble in methanol and acetone, very slightly soluble in ethanol and practically insoluble in water. It has a molecular formula C 21 H 15 N 3 O 4 and molecular weight of 373.36 g/mol. Deferasirox tablets contain 90 mg, 180 mg, or 360 mg deferasirox. Inactive ingredients include colloidal silicon dioxide, crospovidone type A, magnesium stearate, microcrystalline cellulose, polaxamer 188 and povidone. The 90 mg, 180 mg, and 360 mg strength tablets are coated with Opadry Blue, which contains FD&C BLUE #2, hypromellose, polyethylene glycol, talc and titanium dioxide. 10