SPL Set ID: a6c24189-293f-42ca-b969-75870bb55af0
1 drug(s) with this SPL Set ID
Paclitaxel Injection, USP is a clear, colorless to slightly yellow viscous solution. It is supplied as a nonaqueous solution intended for dilution with a suitable parenteral fluid prior to intravenous infusion. Paclitaxel Injection, USP is available in 30 mg (5 mL), 100 mg (16.7 mL), and 300 mg (50 mL) multidose vials. Each mL of sterile nonpyrogenic solution contains 6 mg paclitaxel, USP, 527 mg of polyoxyl 35 castor oil, NF, and 49.7% (v/v) dehydrated alcohol, USP. Paclitaxel is a natural product with antitumor activity. Paclitaxel is obtained via a semi-synthetic process from Taxus baccata . The chemical name for paclitaxel is (2a R ,4 S ,4a S ,6 R ,9 S ,11 S ,12 S ,12a R ,12b S )-1,2a,3,4,4a,6,9,10,11,12, 12a,12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13, 13-tetramethyl-7,11-methano-5 H -cyclodeca[3,4]-benz[1,2- b ] oxet-5-one 6,12b-diacetate, 12-benzoate, 9-ester with (2 R ,3 S )- N-benzoyl-3-phenylisoserine. Paclitaxel has the following structural formula: Paclitaxel, USP is a white to off-white powder with the empirical formula C 47 H 51 NO 14 and a molecular weight of 853.9. It is insoluble in water, soluble in alcohol and melts at around 212°C to 217°C. paclitaxel