SPL Set ID: a603f231-d09e-4bad-ad5e-b55f865da095
1 drug(s) with this SPL Set ID
LEQSELVI (deuruxolitinib) tablets contain the phosphate salt of deuruxolitinib, a Janus kinase (JAK) inhibitor, for oral administration. Deuruxolitinib phosphate is a white to off-white crystalline solid with the chemical name 1 H -Pyrazole-1-propanenitrile, β-(cyclopentyl-2,2,3,3,4,4,5,5- d 8 )-4-(7 H -pyrrolo[2,3- d ]pyrimidin-4-yl)-, (β R )-, phosphate (1:1). Deuruxolitinib has high aqueous solubility at low pH. Deuruxolitinib phosphate has a molecular weight of 412.42 g/mol and a molecular formula of C 17 H 13 D 8 N 6 O 4 P. The structural formula is: Each tablet contains 8 mg of deuruxolitinib (equivalent to 10.50 mg of deuruxolitinib phosphate) and the following excipients: colloidal silicon dioxide, lactose monohydrate, low-substituted hydroxypropyl cellulose, magnesium stearate, microcrystalline cellulose and povidone. The tablet film coating contains the following excipients: carmine, FD&C blue #2 aluminum lake, glyceryl mono and dicaprylocaprate, polyvinyl alcohol, sodium lauryl sulfate, talc, and titanium dioxide. Chemical Structure