SPL Set ID: 95633c32-89a8-4275-94e7-939c9f2e6135
1 drug(s) with this SPL Set ID
Pemetrexed for Injection USP is a folate analog metabolic inhibitor. The drug substance, pemetrexed disodium hemi-pentahydrate, has the chemical name L-glutamic acid, N -[4-[2-(2-amino-4,7-dihydro-4-oxo-1 H -pyrrolo[2,3- d ]pyrimidin-5-yl)ethyl]benzoyl]-, Disodium, hemi-pentahydrate with a molecular formula of C 20 H 19 N 5 Na 2 O 6 •2.5H 2 O and a molecular weight of 516.37. The structural formula is as follows: Pemetrexed for Injection USP is a sterile white-to-light yellow or green-yellow lyophilized powder in single-dose vials to be reconstituted for intravenous infusion. Each 100-mg vial of Pemetrexed for Injection USP contains 100 mg pemetrexed (equivalent to 110.3 mg pemetrexed disodium hemi-pentahydrate) and 106 mg mannitol. Each 500-mg vial of Pemetrexed for Injection USP contains 500 mg pemetrexed (equivalent to 551.4 mg pemetrexed disodium hemi-pentahydrate) and 500 mg mannitol. Hydrochloric acid and/or sodium hydroxide may have been added to adjust pH. Structural Formula