SPL Set ID: 94f069f9-dd52-4a69-a103-ebdb4294f088
1 drug(s) with this SPL Set ID
Esmolol hydrochloride injection is a beta adrenergic receptor blocker with a very short duration of action (elimination half-life is approximately 9 minutes). Esmolol hydrochloride is: • (±)-Methyl p-[2-hydroxy-3-(isopropylamino) propoxy] hydrocinnamate hydrochloride and has the following structure: • Esmolol hydrochloride has the molecular formula C 16 H 26 NO 4 Cl and a molecular weight of 331.8. It has one asymmetric center and exists as an enantiomeric pair. • Esmolol hydrochloride, USP is a white to off-white crystalline powder. It is a relatively hydrophilic compound which is very soluble in water and freely soluble in alcohol. Its partition coefficient (octanol/water) at pH 7.0 is 0.42 compared to 17.0 for propranolol. 11.1 Esmolol Hydrochloride Injection Dosage Forms Esmolol hydrochloride injection is a clear, colorless to light yellow, sterile, nonpyrogenic solution of esmolol hydrochloride. The formulation for esmolol hydrochloride injection is described in the table below: Table 4: Esmolol Hydrochloride Injection Formulation Q.S. = Quantity sufficient Esmolol Hydrochloride Injection Esmolol Hydrochloride, USP 10 mg/mL Water for Injection, USP Q.S. to volume of 10 mL Sodium Acetate Anhydrous, USP 1.688 mg/mL (equivalent to 2.8 mg/mL Sodium Acetate Trihydrate) Glacial Acetic Acid, USP 0.546 mg/mL Sodium Hydroxide Q.S. to adjust pH to 4.5 to 5.5 Hydrochloric Acid Q.S. to adjust pH to 4.5 to 5.5 Esmolol Hydrochloride Structural Formula