SPL Set ID: 8d0e1b59-bd1e-4c6e-9a95-e8143ee076bf
1 drug(s) with this SPL Set ID
Nelarabine is a prodrug of the cytotoxic deoxyguanosine analogue, 9-β- D -arabinofuranosylguanine (ara-G). The chemical name for nelarabine is 2-amino-9-β-D-arabinofuranosyl-6-methoxy-9H-purine. It has the molecular formula C 11 H 15 N 5 O 5 and a molecular weight of 297.27 g/mol. Nelarabine has the following structural formula: Nelarabine is a white to off-white solid. It is soluble in dimethylformamide, slightly soluble in water, and practically insoluble in acetone. It melts with decomposition between 209°C and 214°C. Nelarabine Injection, 250 mg/50 mL (5 mg/mL) is available as a sterile, clear, colorless solution filled in clear glass single-dose vials. Each vial contains 250 mg of nelarabine (5 mg nelarabine per mL) and the inactive ingredient sodium chloride (4.5 mg per mL) in 50 mL Water for Injection, USP. Nelarabine injection is intended for intravenous infusion. Hydrochloric acid and sodium hydroxide may have been used to adjust the pH. The solution pH ranges from 5.0 to 7.0. 1