SPL Set ID: 8b660f68-b770-4e0a-b2f9-25e663deecc3
1 drug(s) with this SPL Set ID
Pemetrexed is a folate analog metabolic inhibitor. The drug substance, pemetrexed diacid monohydrate, has the chemical name N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1 H -pyrrolo[2,3- d ] pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, monohydrate with a molecular formula of C 20 H 21 N 5 O 6 • H 2 O and a molecular weight of 445.43. It is practically insoluble in water. The structural formula is as follows: Pemetrexed Injection is supplied as a sterile solution for intravenous infusion available in single-dose vials. The product is a clear to slightly yellowish or slightly yellow-greenish solution. Each mL contains 25 mg pemetrexed, 35 mg tromethamine, 10 mg citric acid anhydrous, 0.5 mg methionine and water for injection. Tromethamine may have been added to adjust pH. 1