SPL Set ID: 87c5a534-4321-46c7-9938-84dca34b6506

Brimonidine tartrate ophthalmic solution, 0.1%, sterile, is a relatively selective alpha-2 adrenergic receptor agonist for topical ophthalmic use. The structural formula of brimonidine tartrate is: 5-Bromo-6-(2-Imidazolin-2-ylamino)quinoxaline Tartrate; MW = 442.22 In solution, brimonidine tartrate ophthalmic solution, 0.1% has a clear, greenish-yellow color. It has an osmolality of 255 to 300 mOsmol/kg and a pH of 7.5 to 7.8. Brimonidine tartrate appears as an white to off-white, pale yellow to yellow powder and is soluble in both water (0.6 mg/mL) and in the product vehicle (1.4 mg/mL) at pH 7.7. Each mL of brimonidine tartrate ophthalmic solution, 0.1% contains: Active ingredient: brimonidine tartrate 0.1% (1 mg/mL). Preservative: sodium chlorite 0.005% (0.05 mg/mL). Inactives: boric acid; calcium chloride; magnesium chloride; potassium chloride; sodium borate; sodium carboxymethylcellulose; sodium chloride and purified water. Hydrochloric acid/or sodium hydroxide may be added to adjust pH. structure