SPL Set ID: 82a84f69-4742-453f-96c8-532fb7df44c6

Prazosin hydrochloride capsules, USP a quinazoline derivative, is the first of a new chemical class of antihypertensives. It is the hydrochloride salt of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl) piperazine and its structural formula is: Molecular formula C 19 H 21 N 5 O 4 •HCl It is white or almost white crystalline powder, very slightly soluble in water, slightly soluble in methanol, in dimethylformamide, in dimethylacetamide and in alcohol; practically insoluble in chloroform and in acetone, and has a molecular weight of 419.87. Each capsule, for oral use, contains prazosin hydrochloride, USP equivalent to 1 mg, 2 mg or 5 mg of prazosin. Inert ingredients in the formulations are: colloidal silicon dioxide, magnesium stearate, sodium starch glycolate, sucrose. The empty hard gelatin capsule shells contain gelatin and titanium dioxide. In addition, the 2 mg and 5 mg empty hard gelatin capsule shells contains D&C Red 28, FD&C Blue 1 and FD&C Red 40. The Imprint ink contains black iron oxide, potassium hydroxide, propylene glycol and shellac. FDA approved dissolution test specifications differ from USP. structure