SPL Set ID: 7bed5d8c-30c2-4598-acf3-2edba825a56d
1 drug(s) with this SPL Set ID
Nicardipine hydrochloride capsules for oral administration each contain 20 mg or 30 mg of nicardipine hydrochloride. Nicardipine hydrochloride capsules are a calcium ion influx inhibitor (slow channel blocker or calcium channel blocker). Nicardipine hydrochloride is a dihydropyridine structure with the IUPAC (International Union of Pure and Applied Chemistry) chemical name 2-(benzyl-methyl amino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate monohydrochloride, and it has the following structure: Nicardipine hydrochloride is a greenish-yellow, odorless, crystalline powder that melts at about 169°C. It is freely soluble in chloroform, methanol and glacial acetic acid, sparingly soluble in anhydrous ethanol, slightly soluble in n-butanol, water, 0.01 M potassium dihydrogen phosphate, acetone and dioxane, very slightly soluble in ethyl acetate, and practically insoluble in benzene, ether and hexane. It has a molecular weight of 515.99. Nicardipine hydrochloride capsules are available in hard gelatin capsules containing 20 mg or 30 mg nicardipine hydrochloride with colloidal silicon dioxide, lactose monohydrate, magnesium stearate, pregelatinized starch, and sodium starch glycolate as the inactive ingredients. The 20-mg strength is provided in white opaque body and light blue opaque cap, hard gelatin capsules imprinted “NIC 1” in black ink on cap and body, filled with yellow color granular powder, while the 30-mg capsules are light blue opaque body and blue opaque cap, hard gelatin capsules imprinted “NIC 2” in black ink on cap and body, filled with yellow color granular powder. The capsule shells contain black imprint ink, FD&C blue #1, gelatin, and titanium dioxide. The black imprinting ink contains black iron oxide, butyl alcohol, dehydrated alcohol, isopropyl alcohol, potassium hydroxide, propylene glycol, shellac, and strong ammonia solution. structure