SPL Set ID: 79ad107b-bb20-4ed3-89f0-d7c862f3957c
1 drug(s) with this SPL Set ID
Donepezil hydrochloride is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as (±)-2, 3-dihydro-5, 6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride. Donepezil hydrochloride is commonly referred to in the pharmacological literature as E2020. It has a molecular formula of C 24 H 29 NO 3 HCl and a molecular weight of 415.96. Donepezil hydrochloride is a white crystalline powder and is freely soluble in chloroform, soluble in water and in glacial acetic acid, slightly soluble in ethanol and in acetonitrile, and practically insoluble in ethyl acetate and in n-hexane. Donepezil hydrochloride tablets, USP are available for oral administration in film-coated tablets containing 5 mg or 10 mg of donepezil hydrochloride, USP. Inactive ingredients in 5 mg and 10 mg tablets are lactose monohydrate, corn starch, microcrystalline cellulose, hydroxypropyl cellulose, low substituted hydroxypropyl cellulose, talc and magnesium stearate. The film coating contains talc, polyethylene glycol, hypromellose and titanium dioxide. Additionally, the 10 mg tablet contains yellow iron oxide as a coloring agent. Donepezil hydrochloride tablets are available for oral administration in film-coated tablets containing 23 mg of donepezil hydrochloride, USP. Inactive ingredients in 23 mg tablets include lactose monohydrate, microcrystalline cellulose, hypromellose, methacrylic acid copolymer Type C, and magnesium stearate. The film coating includes hypromellose, iron oxide yellow, polyethylene glycol, iron oxide red, titanium dioxide and lactose monohydrate. USP dissolution test pending for 23 mg tablet. spl-donepezil-structure