SPL Set ID: 79591576-1eab-48c5-b0a6-e205b3cc097e
1 drug(s) with this SPL Set ID
Fluocinolone Acetonide Oil (Ear Drops) contains fluocinolone acetonide [(6α, 11β, 16α)-6,9-difluoro-11,21-dihydroxy-16, 17[(1-methylethylidene)bis(oxy)]- pregna-1,4-diene3,20-dione, cyclic 16,17 acetal with acetone], a synthetic corticosteroid for topical dermatologic use. Chemically, fluocinolone acetonide is C 24 H 30 F 2 O 6 . It has the following structural formula: Fluocinolone acetonide has a molecular weight of 452.50. It is a white crystalline powder that is odorless, stable in light, and melts at 270°C with decomposition; soluble in alcohol, acetone and methanol; slightly soluble in chloroform; insoluble in water. Each gram of fluocinolone acetonide oil contains approximately 0.11 mg of fluocinolone acetonide in a blend of oils, which contains isopropyl alcohol, isopropyl myristate, light mineral oil, oleth-2 and refined peanut oil. Fluocinolone acetonide oil is formulated with 48% refined peanut oil. The bulk refined peanut oil, used in fluocinolone acetonide oil is heated between 232°C - 246°C (450°F - 475°F) for at least 15 minutes, which should provide for adequate decomposition of allergenic proteins. Fluocinolone -structure.jpg