SPL Set ID: 68c4e9dc-dbcf-4151-b6f7-5e4b9922b76f
1 drug(s) with this SPL Set ID
TALICIA delayed-release capsules contain omeprazole magnesium, amoxicillin and rifabutin for oral administration. Omeprazole magnesium is included in the delayed-release component of the capsule, and amoxicillin and rifabutin are included in the immediate-release component of the capsule. Each delayed-release capsule contains: omeprazole 10 mg (equivalent to 10.3 mg of omeprazole magnesium) amoxicillin 250 mg (equivalent to 286.9 mg of amoxicillin trihydrate) rifabutin 12.5 mg Omeprazole magnesium is a proton pump inhibitor. Amoxicillin and rifabutin are antibacterial drugs. Each TALICIA delayed-release capsule contains the following inactive ingredients: crospovidone, FD&C Red 3, FD&C Yellow 6, gelatin, hydroxypropyl cellulose, hypromellose, magnesium stearate, mannitol-starch, methacrylic acid copolymer, meglumine, pregelatinized starch, silica, sodium bicarbonate, sodium lauryl sulfate, talc, titanium dioxide and triethyl citrate. Omeprazole Magnesium Omeprazole magnesium is a white to off-white powder with a melting point with degradation at 200 °C. The salt is slightly soluble (0.25 mg/mL) in water at 25 °C, and it is soluble in methanol. Omeprazole magnesium is 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl) methyl] sulfinyl]benzimidazole, (RS) magnesium salt (2:1). Omeprazole magnesium has a molecular formula of (C 17 H 19 N 3 O 3 S) 2 Mg, and a molecular weight of 713.12. The structural formula is: Amoxicillin Amoxicillin is a semisynthetic antibacterial drug, an analog of ampicillin. Chemically it is (2 S ,5 R ,6 R )-6-[( R )-(-)-2- amino-2-( p -hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylic acid trihydrate. Amoxicillin has a molecular formula of C 16 H 19 N 3 O 5 S•3 H 2 O, and a molecular weight of 419.45. The structural formula is: Rifabutin Rifabutin is a red-violet powder soluble in chloroform and methanol, sparingly soluble in ethanol, and very slightly soluble in water (0.19 mg/mL). Its log P value (the base 10 logarithm of the partition coefficient between n-octanol and water) is 3.2 (n-octanol/water). Rifabutin is (9S,12E,14S,15R,16S,17R,18R,19R,20S,21S,22E,24Z)-6-16,18,20-tetrahydroxy-1'-isobutyl-14-methoxy-7,9,15,17,19,21,25-heptamethylspiro [9,4-(epoxypentadeca[1,11,13]trienimino)-2H-furo[2',3':7,8]naphth[1,2-d] imidazole-2,4'-piperidine]-5,10,26-(3H,9H)-trione-16-acetate. Rifabutin has a molecular formula of C 46 H 62 N 4 O 11 , and a molecular weight of 847.02. The structural formula is: Rifabutin Chemical Structure Amoxicillin Chemical Structure Omeprazole Magnesium Chemical Structure