SPL Set ID: 49e9c804-9e88-4774-8faf-35bd61b3a8e9

Mesna injection is a detoxifying agent to inhibit the hemorrhagic cystitis induced by ifosfamide. The active ingredient, mesna, USP is a synthetic sulfhydryl compound designated as sodium-2- sulphanylethanesulphonate with a molecular formula of C 2 H 5 NaO 3 S 2 and a molecular weight of 164.2. Its structural formula is as follows: HS–CH 2 –CH 2 SO 3 –Na + Mesna injection is a sterile, nonpyrogenic, aqueous solution of clear and colorless appearance in clear glass multiple-dose vials for intravenous administration. Mesna injection contains 100 mg/mL mesna, USP, 0.25 mg/mL edetate disodium and sodium hydroxide for pH adjustment. Mesna injection multiple-dose vials also contain 10.4 mg/mL of benzyl alcohol as a preservative. The solution has a pH range between 7.5 and 8.5.