SPL Set ID: 49e5afe9-a0c7-40c4-af9f-f287a80c5c88

Denosumab is a human IgG2 monoclonal antibody with affinity and specificity for human RANKL (receptor activator of nuclear factor kappa-B ligand). Denosumab has an approximate molecular weight of 147 kDa and is produced in genetically engineered mammalian (Chinese hamster ovary) cells. Prolia (denosumab) injection is a sterile, preservative-free, clear, colorless to pale yellow solution for subcutaneous use. Each single-dose prefilled syringe contains 1 mL solution of 60 mg denosumab, glacial acetic acid (1 mg), polysorbate 20 (0.1 mg), sorbitol (47 mg), Water for Injection (USP), and sodium hydroxide to adjust the pH to 5.2.