SPL Set ID: 2da33e5b-dcfb-4cdf-b163-50398e42f41c

MYLERAN (busulfan) is a bifunctional alkylating agent. Busulfan is known chemically as 1,4-butanediol dimethanesulfonate and has the following structural formula: CH 3 SO 2 O(CH 2 ) 4 OSO 2 CH 3 Busulfan is not a structural analog of the nitrogen mustards. MYLERAN is available in tablet form for oral administration. Each film-coated tablet contains 2 mg busulfan and the inactive ingredients hypromellose, lactose (anhydrous), magnesium stearate, pregelatinized starch, triacetin, and titanium dioxide. The activity of busulfan in chronic myelogenous leukemia was first reported by D.A.G. Galton in 1953. Chem Structure