SPL Set ID: 29891f95-9079-4880-7abc-194e49767dd5

Gengraf ® Oral Solution (cyclosporine oral solution, USP [ MODIFIED ]) is a modified oral formulation of cyclosporine that forms an aqueous dispersion in an aqueous environment. Cyclosporine, the active principle in Gengraf ® Oral Solution, is a cyclic polypeptide immunosuppressant agent consisting of 11 amino acids. It is produced as a metabolite by the fungus species Aphanocladium album . Chemically, cyclosporine is designated as [R-[R*,R*-(E)]]-cyclic-(L-alanyl-D-alanyl- N -methyl-L-leucyl- N -methyl-L-leucyl- N -methyl-L-valyl-3-hydroxy- N ,4-dimethyl-L-2-amino-6-octenoyl-L-α-amino-butyryl- N -methylglycyl- N -methyl-L-leucyl-L-valyl- N -methyl-L-leucyl). Gengraf ® Oral Solution (cyclosporine oral solution, USP [ MODIFIED ]) is available in 50 mL bottles. Each mL contains: cyclosporine 100 mg/mL. Chemical structure for cyclosporine USP. Inactive Ingredients Polyoxyl 40 hydrogenated castor oil NF, propylene glycol USP, sorbitan monooleate NF. The chemical structure for cyclosporine USP is: