SPL Set ID: 242c2512-1d49-486b-a9c3-6905f667799e

Morphine sulfate oral solution is an opioid agonist, available in the following concentration for oral administration: 100 mg per 5 mL (20 mg/mL) : Each 1 mL of oral solution contains 20 mg of morphine sulfate, USP (equivalent to 15 mg morphine). The chemical name is 7,8-didehydro-4,5 alpha-epoxy-17-methyl-morphinan-3,6 alpha-diol sulfate (2:1) (salt) pentahydrate. The molecular weight is 758.83. Its molecular formula is (C 17 H 21 NO 3 ) 2 •H 2 SO 4 •5Η 2 Ο, and it has the following chemical structure. Morphine sulfate, USP is a white to off-white crystalline powder or a fine white to light yellow powder. It is soluble in water and slightly soluble in alcohol, but is practically insoluble in chloroform or ether. The octanol:water partition coefficient of morphine is 1.42 at physiologic pH and the pK a is 7.9 for the tertiary nitrogen (the majority is ionized at pH 7.4). For the 100 mg per 5 mL (20 mg/mL) concentration (only for opioid-tolerant adults) : Each 5 mL of oral solution contains 100 mg of morphine sulfate, USP and the following inactive ingredients: anhydrous citric acid, edetate disodium, FD&C Green No. 3, glycerin, purified water, raspberry cream flavor and sodium benzoate. The pH of the solution is adjusted with diluted hydrochloric acid, as needed. Chemical Structure