SPL Set ID: 200ab93b-6ad3-46cb-8f57-db056a14de16

Bisoprolol fumarate USP is a synthetic, beta 1 -selective (cardioselective) adrenoceptor blocking agent. The chemical name for bisoprolol fumarate is 2-Propanol,1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-,(±)-,( E )-2-butenedioate (2:1) (salt) . It possesses an asymmetric carbon atom in its structure and is provided as a racemic mixture. The S(-) enantiomer is responsible for most of the beta-blocking activity. Its molecular formula is (C 18 H 31 NO 4 ) 2 •C 4 H 4 O 4 and its structure is: Bisoprolol fumarate has a molecular weight of 766.96. It is a white crystalline powder which is approximately equally hydrophilic and lipophilic, and is very soluble in water and in methanol. Freely soluble in chloroform, glacial acetic acid, and in ethanol, slightly soluble in acetone and in ethyl acetate. Bisoprolol fumarate tablets, USP are available as 5 and 10 mg tablets for oral administration. Inactive ingredients include Anhydrous Dibasic Calcium Phosphate, Colloidal Silicon Dioxide, Crospovidone, Hypromellose, Magnesium Stearate, Microcrystalline Cellulose, Polyethylene Glycol, Polysorbate 80, Pregelatinized Starch and Titanium Dioxide. The 5 mg tablets also contain Red and Yellow Iron Oxide. Meets USP Dissolution Test 3. bisoprolol-fumarate-structure