SPL Set ID: 1d8bcf03-e055-a274-7844-ae9a523e3c4c
1 drug(s) with this SPL Set ID
Pemetrexed for injection, USP is a folate analog metabolic inhibitor. The drug substance, pemetrexed disodium (Amorphous), has the chemical name L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt. It is a white to cream color powder with a molecular formula C 20 H 19 N 5 Na 2 O 6 and a molecular weight of 471.48. The pH of 1% solution is between 7.5 and 8.4. The structural formula is as follows: Pemetrexed for injection, USP is supplied as a sterile lyophilized powder for intravenous infusion available in single-dose vials. The product is a white to either light-yellow or green-yellow lyophilized powder. Each 100 mg, 500 mg, or 1 g vial of pemetrexed for injection, USP contains pemetrexed disodium equivalent to 100 mg pemetrexed and 106 mg mannitol, 500 mg pemetrexed and 500 mg mannitol, or 1 g pemetrexed and 1 g mannitol, respectively. Hydrochloric acid and/or sodium hydroxide may have been added to adjust pH.