SPL Set ID: 19cf46b5-d8dc-44cb-83d6-bacea0870dbe

Tizanidine capsules contain tizanidine hydrochloride as the active ingredient, which is a central alpha 2 -adrenergic agonist. Its chemical name is 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole monohydrochloride. It has a molecular formula of C 9 H 8 ClN 5 S-HCl and a molecular weight of 290.2. Its structural formula is: Tizanidine hydrochloride is almost white to slightly yellow, crystalline powder. Tizanidine hydrochloride is slightly soluble in water and methanol; solubility in water decreases as the pH increases. Tizanidine capsules are for oral administration and contain 2, 4, or 6 mg tizanidine (equivalent to 2.287 mg, 4.575 mg, and 6.862 mg tizanidine hydrochloride USP, respectively), and the inactive ingredients black iron oxide, D&C yellow 10, FD & C blue 1, gelatin, hypromellose, potassium hydroxide, shellac, silicon dioxide, sugar spheres (which contains starch (maize) and sucrose) and titanium dioxide. In addition 2 mg contains FD & C red 40, 4 mg and 6 mg contains FD&C yellow 6. Chemical Structure