SPL Set ID: 19880f51-badb-4846-a02a-592a210690ab
1 drug(s) with this SPL Set ID
Sirolimus is an mTOR inhibitor immunosuppressive agent. Sirolimus is a macrocyclic lactone produced by Streptomyces hygroscopicus . The chemical name of sirolimus (also known as rapamycin) is (3 S ,6 R ,7 E ,9 R ,10 R ,12 R ,14 S ,15 E ,17 E ,19 E ,21 S , 23 S ,26 R ,27 R , 34a S )-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a hexadecahydro-9,27-dihydroxy-3-[(1 R )-2-[(1 S ,3 R ,4 R )-4-hydroxy-3- methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27 epoxy-3 H -pyrido[2,1-c][1,4] oxaazacyclohentriacontine-1,5,11,28,29 (4 H ,6 H ,31 H )-pentone. Its molecular formula is C 51 H 79 NO 13 and its molecular weight is 914.2. The structural formula of sirolimus is illustrated as follows. Sirolimus is a white to off-white powder and is practically insoluble in water, but freely soluble in acetone, dimethyl sulfoxide and methanol. Sirolimus is available for administration as an oral solution containing 1 mg/mL sirolimus. The inactive ingredients in Sirolimus Oral Solution are Phosal® 50 PG (alcohol, ascorbyl palmitate, phosphatidylcholine, propylene glycol, soy acid, soy lecithin, sunflower seed oil glyceride, and tocopherol) and polysorbate 80. Sirolimus Oral Solution contains 1.5% - 2.5% ethanol. structure