SPL Set ID: 175d8b87-e06a-4c9e-b3de-378114b52274
1 drug(s) with this SPL Set ID
Mycophenolate mofetil is an antimetabolite immunosuppressant. It is the 2 morpholinoethyl ester of mycophenolic acid (MPA), an immunosuppressive agent; inosine monophosphate dehydrogenase (IMPDH) inhibitor. The chemical name for mycophenolate mofetil (MMF) is 2-morpholinoethyl (E)-6-(1,3dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoate. It has an empirical formula of C 23 H 31 NO 7 , a molecular weight of 433.50, and the following structural formula: MMF is a white to off-white crystalline powder. It is slightly soluble in water (43 mcg/mL at pH 7.4); the solubility increases in acidic medium (4.27 mg/mL at pH 3.6). It is freely soluble in acetone, soluble in methanol, and sparingly soluble in ethanol. The apparent partition coefficient in 1-octanol/water (pH 7.4) buffer solution is 238. The pKa values for MMF are 5.6 for the morpholino group and 8.5 for the phenolic group. Mycophenolate mofetil is available for oral administration as a powder for oral suspension which, when reconstituted, contains 200 mg/mL of MMF. Inactive ingredients in Mycophenolate mofetil for Oral Suspension include aspartame, banana flavor (contains arabic gum, natural flavor, potato maltodextrin, medium chain triglycerides), citric acid anhydrous, colloidal silicon dioxide, isopropyl alcohol*, lecithin granular, methylparaben, sodium citrate dihydrate, sorbitol, and xanthan gum. *evaporated during processing; negligible amount may be present. Net contents after constitution: 175 mL, containing 35 grams mycophenolate mofetil. Deliverable volume after constitution: 160-165 mL. structure