SPL Set ID: 15d08594-83a9-cc7a-92ef-1bac0427e121

Penicillamine USP is a chelating agent used in the treatment of Wilson's disease. It is also used to reduce cystine excretion in cystinuria and to treat patients with severe, active rheumatoid arthritis unresponsive to conventional therapy (see INDICATIONS ). It is 3-mercapto-D-valine. It is a white or practically white, crystalline powder, freely soluble in water, slightly soluble in alcohol, and insoluble in chloroform and ether. Although its configuration is D, it is levorotatory as usually measured: [α] 25° = -62.5° ± 2° (c = 1, 1N NaOH), D calculated on a dried basis. The molecular formula is C 5 H 11 NO 2 S, giving it a molecular weight of 149.21. The structural formula is: It reacts readily with formaldehyde or acetone to form a thiazolidine-carboxylic acid. Penicillamine Capsules USP, for oral administration contains 250 mg of penicillamine. Each capsule contains the following inactive ingredients: Black iron oxide, gelatin, microcrystalline cellulose, magnesium stearate, potassium hydroxide, propylene glycol, shellac, strong ammonia solution and titanium dioxide.