SPL Set ID: 1539fbf9-8281-4c7b-827b-9f53b50d9042

Pomalidomide is a thalidomide analog. The chemical name is (RS)-4-Amino-2-(2,6-dioxo-­piperidin-3-yl)-isoindoline-1,3-dione and it has the following chemical structure: The empirical formula for pomalidomide is C 13 H 11 N 3 O 4 and the gram molecular weight is 273.24. Pomalidomide is yellow crystalline powder. It is practically insoluble in water and chloroform, very slightly soluble in methanol and acetone. Pomalidomide has a chiral carbon atom which exists as a racemic mixture of the R(+) and S(-) enantiomers. Pomalidomide is available in 1 mg, 2 mg, 3 mg, and 4 mg capsules for oral administration. Each capsule contains pomalidomide as the active ingredient and the following inactive ingredients: mannitol and pregelatinized starch (maize). The empty hard gelatin capsule shell contains gelatin, iron oxide red and titanium dioxide. In addition, 3 mg capsule shell contains iron oxide black and 4 mg capsule shell contains D&C yellow 10, FD&C blue 1 and FD&C red 3. The capsule shells are printed with edible ink containing iron oxide black, potassium hydroxide, propylene glycol, shellac and strong ammonia solution. Chemical Structure