SPL Set ID: 13c9c37a-0c3d-450a-a61e-d2796818b18f

Isoflurane USP, a nonflammable liquid administered by vaporizing, is a general inhalation anesthetic drug. It is 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, and its structural formula is: iso structure Some physical constants are: Molecular weight 184.5 Boiling point at 760 mm Hg 48.5°C Refractive index n 20/D 1.2990-1.3005 Specific gravity 25°/25°C 1.496 Vapor pressure in mm Hg** 20°C 238 25°C 295 30°C 367 35°C 450 **Equation for vapor pressure calculation: log 10 P vap = A + B/T where: A = 8.056 B = −1664.58 T = °C + 273.16 (Kelvin) Partition coefficients at 37°C Water/gas Blood/gas Oil/gas 0.61 1.43 90.8 Partition coefficients at 25°C -rubber and plastic Conductive rubber/gas Butyl rubber/gas Polyvinyl chloride/gas Polyethylene/gas Polyurethane/gas Polyolefin/gas Butyl acetate/gas Purity by gas chromatography 62.0 75.0 110.0 ~2.0 ~1.4 ~1.1 ~2.5 >99.9% Lower limit of flammability in oxygen or nitrous oxide at 9 joules/sec. and 23°C None Lower limit of flammability in oxygen or nitrous oxide at 900 concentration in joules/sec. and 23°C Greater than useful concentration in anesthesia. Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor. Samples stored in indirect sunlight in clear, colorless glass for five years, as well as samples directly exposed for 30 hours to a 2 amp, 115 volt, 60 cycle long wave U.V. light were unchanged in composition as determined by gas chromatography. Isoflurane in one normal sodium methoxide-methanol solution, a strong base, for over six months consumed essentially no alkali, indicative of strong base stability. Isoflurane does not decompose in the presence of soda lime (at normal operating temperatures), and does not attack aluminum, tin, brass, iron or copper.