SPL Set ID: 0c7fd6ab-2ce5-4110-b6e6-9103c8da0765
1 drug(s) with this SPL Set ID
Memantine hydrochloride extended-release capsules is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula: The molecular formula is C 12 H 21 N•HCl and the molecular weight is 215.76. Memantine hydrochloride occurs as a fine white to off-white powder and is soluble in water. Memantine hydrochloride extended-release capsules are supplied for oral administration as 7 mg, 14 mg, 21 mg and 28 mg capsules. Among them, 7 mg strength is supplied in opaque light green cap and opaque white body capsule, with "LPM" black imprint on the cap and "7 mg" black imprint on the body, 14 mg strength is supplied in opaque blue cap and opaque white body capsule, with "LPM" black imprint on the cap and "14 mg" black imprint on the body, 21 mg strength is supplied in opaque white cap and opaque white body capsule, with "LPM" black imprint on the cap and "21 mg" black imprint on the body, 28 mg strength is supplied in the opaque rich yellow cap and opaque white body capsule, with "LPM" black imprint on the cap and "28 mg" black imprint on the body. Each capsule contains extended-release white to off-white beads with the labeled amount of memantine hydrochloride and the following inactive ingredients: sugar spheres (sucrose, maize starch, and dextrin), polyvinylpyrrolidone, hypromellose, talc, polyethylene glycol, triethyl citrate, ethylcellulose, ammonium hydroxide, oleic acid, and medium chain triglycerides in hard gelatin capsules. In addition, the capsule shells contain gelatin and titanium dioxide and are imprinted with black ink. Colorants in capsule shells are brilliant blue (7 mg, 14 mg), erythrosine (14 mg only) and ferric oxide yellow (7 mg, 28 mg). The black ink mainly contains shellac, black iron oxide, dehydrated alcohol, purified water and propylene glycol, with trace amount of isopropyl alcohol, butyl alcohol, strong ammonia solution and potassium hydroxide. Structure