SPL Set ID: 052e6fe3-d619-42c3-b64e-67c7aaf7271c
1 drug(s) with this SPL Set ID
Naproxen Delayed-Release Tablets, USP are nonsteroidal anti-inflammatory drugs available as enteric-coated tablets containing 375 mg of naproxen or 500 mg of naproxen for oral administration. Naproxen is a propionic acid derivative related to the arylacetic acid group of nonsteroidal anti-inflammatory drugs. The chemical name for naproxen is (S)-6-methoxy-α-methyl-2-naphthaleneacetic acid. Naproxen has a molecular weight of 230.26 and a molecular formula of C 14 H 14 O 3 with the following structure: Naproxen is an odorless, white to off-white crystalline substance. It is lipid-soluble, practically insoluble in water at low pH and freely soluble in water at high pH. The octanol/water partition coefficient of naproxen at pH 7.4 is 1.6 to 1.8. The inactive ingredients in Naproxen Delayed-Release Tablets, USP include: croscarmellose sodium, povidone, colloidal silicon dioxide and magnesium stearate. The enteric coating dispersion contains methacrylic acid and ethyl acrylate copolymer, triethyl citrate, talc and purified water. The dissolution of this enteric-coated naproxen tablet is pH dependent with rapid dissolution above pH 6. There is no dissolution below pH 4. structure