SPL Set ID: 03450d2d-97ce-4518-af15-ab85b0d65d76

Bupropion hydrochloride tablets USP, an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Its structure closely resembles that of diethylpropion; it is related to phenylethylamines. It is designated as (±)-1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1­- propanone hydrochloride. The molecular weight is 276.2. The molecular formula is C 13 H 18 ClNO•HCl. Bupropion hydrochloride USP is white powder, soluble in water in 0.1 N hydrochloric acid, and in alcohol. It has a bitter taste and produces the sensation of local anesthesia on the oral mucosa. The structural formula is: Bupropion hydrochloride tablets USP are supplied for oral administration as 75 mg (yellow) and 100 mg (red) film-coated tablets. Each tablet contains the labeled amount of bupropion hydrochloride and the inactive ingredients: 75 mg tablets contains cysteine hydrochloride, Low-substituted hydroxypropyl cellulose, hypromellose, microcrystalline cellulose, stearic acid, D&C yellow No.10 aluminum lake, triacetin, titanium dioxide, FD&C yellow No 6, hydroxypropyl cellulose. 100 mg tablets contains cysteine hydrochloride, Low-substituted hydroxypropyl cellulose, hypromellose, microcrystalline cellulose, stearic acid, triacetin, FD&C Red No 40, FD&C yellow No 6, titanium dioxide, hydroxypropyl cellulose. structure